psi up the wazoo

okay, so me and my brother were talking about this, but we weren't to sure about the outcome, so i came here. heres the back-drop

okay, most people usually get lower compression pistons after a turbo. but doing that makes your car slower then what it was before the turbo. so basicly they up the turbo even more figure that they can and it won't hurt the engine as bad.

so what im trying to get at is. will less pounds of boost with a higher compression gonna make your car last any longer then a car with higher pounds oh boost with lower compression?

hey, thanks in advance to anyone that has the answer =)